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Cialis vs Viagra What's the difference between them - Daily News. Cialis and Viagra are both PDE5 inhibitors used for the treatment of erectile dysfunction (ED). Both only work when a man is sexually aroused. Cialis lasts for around 36 hours compared with only 4 to 5 hours for Viagra. Food does not affect the activity of Cialis, whereas food may decrease the effectiveness of Viagra. Cialis can be used once daily, at a smaller dosage, and is also effective at treating benign prostatic hyperplasia (BPH). Dosage of Cialis may need to be reduced in men with liver or kidney problems and risk of interactions may be higher than with Viagra.
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