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CJD Creutzfeldt-Jakob Disease - Mayo Clinic

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There is a disease that strikes just 300 Americans each year. Yet, it is a nightmare that some have described as a lightening quick version of Alzheimer's & Parkinson's diseases combined. For families losing loved ones, research holds the only hope. Here's Dennis Douda for Medical Edge.
Категория: Наука и техника
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Текстовые комментарии (42)
Doomtrigger (2 месяца назад)
she ate baby brains
ron rupska (2 месяца назад)
There were a cluster of deaths from meat consumed at a New Jersey horse track
Alex Dash (2 месяца назад)
There is kind of a cause. It can be passed down by sperm which is a small chance, or it could be in any meat you eat, along with certain surgeries. That's why I'm a vegetarian now other than the fact that cows have feelings along with other animals. This disease can kill you slowly and take years or kill you in a week. You never know when the person will die. You can be 15 and get it or 60 and get it. I havent had it in my family, but I do know alot about it. This video needs to be revised. Also someone in the comments said it can happen with deer and elk but that's not what cjd is. That would be chronic wasting disease and is a totally different factor.
Blah BlahBlah (10 месяцев назад)
I was just told Im a candidate to develop this desiese, .. Im scared :(
Jesus wept. (1 год назад)
Prion diseases like CJD or Kuru in humans and BSE in animals are in-built evolutionary fail safes. Cannibalism harms the species because it defies the concept of survival. Ask yourself, how can a species thrive if it eats itself? By feeding herbivore cows the brains of other cows in modern agricultural practices, we effectively bypassed evolution and thus created a new anomaly. This anomaly takes the form of the most fatal diseases known to mankind. If we don't learn these lessons we are doomed to create the deadliest plague in human history as we unknowingly consume this tainted meat.
Borrusimo B (2 месяца назад)
Didn't they say this case was familial?
drwanderlust (2 месяца назад)
Well said. I gave a lengthy presentation on CJD and BSE during my doctoral program in clinical psych. I was terrified by what I learned, and then I terrified my cohort. I remember reading that, not only are these diseases virtually indestructible, they can spontaneously appear without exposure. While very rare, it is possible for the mutation of this misshaped protein to sporadically appear and destroy lives . These diseases can remain dormant for years, so it would be next to impossible to pinpoint specific details of transmission. I find these diseases both frightening and fascinating at the same time, especially from an evolutionary/psychological perspective. For my research project, I went as far back as Kuru in Papau New Guinea, and I believe there was cannibalism (as a cultural tradition?) and possibly a river where dead and diseased bodies were tossed in, which was also a source of water for this village. I digress. My main purpose for commenting was to touch on your statement about prions as evolutionary failsafes. While feeding normal cows with ground up, infected brain matter from cows with BSE, that will certainly kill them. BUT, even in the hypothetical event that this horrific practice no longer occurred, the disease could, and likely would, live on. Sporadic mutation. It reminds me of the first Jurassic Park when the eccentric scientist (who talks about chaos theory) finds it hysterical that the lab attempted to place constraints on the Raptors (and inability to breed) by engineering females. The lab used a strain of frog DNA that, unbeknownst to them, had the ability to change sex when in an environment that inhibited its survival. I think it was Jeff Goldblum who said something like, no matter how many constraints we try and place on life to try and contain it, it will find a way. Humans must live and humans must die. To what extent are we, as humans, disrupting the natural progression of life and death? Very difficult questions to think about. Two other prion diseases of interest are chronic wasting disease and fatal familial insomnia.
fenton bevan (1 год назад)
cjd and mad cows disease is a fraud. they painted organophosphates onto the cows (and other animals). research concentrated organophosphate painted onto cows. research what organophosphates do to people (and cows)
Jennifer Spaeth (1 год назад)
sad that this is often undiagnosed, many states dont report even suspected cases to the CDC. working in nursing, its scary how many illnesses are undiagnosed, or misdiagnosed... even in autopsies.
drwanderlust (2 месяца назад)
this is scary, especially knowing how indestructible these diseases are even with the most extreme precautions.
Dave K (1 год назад)
My father died in 1978 from CJD. It was horrific. I hope a cure is found someday.
justjohnny05 (2 года назад)
There are many different versions of Prion illnesses some can last 10 years or more our family has a hereditary version where we all are increasingly ill over a 10 year period we lost my uncle my grandma and now I am doing very poorly now im guessing the final stage could happen at any time.
thedans857 (2 года назад)
1- 1000000
vgnorweck (5 месяцев назад)
thedans857 now 1 in 2000 expected and approximately since states don't gave to report and often autopsies aren't done and in autopsy it's contagious which is probably why they don't want to do them and why then no reposting
YetMorePlaying (2 года назад)
My gradfather died from this. My family never told me if he had the sporadic kind or not. I guess they might be afraid that I get it too.
Jonathan shulskie (2 года назад)
+明明如月 he was most likely born with it and I believe once you reach around sixty the symptoms start popping up.
Jonathan shulskie (2 года назад)
+明明如月 that's a completely different disease.
Terry Singeltary (3 года назад)
O.05: Transmission of prions to primates after extended silent incubation periods: Implications for BSE and scrapie risk assessment in human populations   Emmanuel Comoy, Jacqueline Mikol, Val erie Durand, Sophie Luccantoni, Evelyne Correia, Nathalie Lescoutra, Capucine Dehen, and Jean-Philippe Deslys Atomic Energy Commission; Fontenay-aux-Roses, France   Prion diseases (PD) are the unique neurodegenerative proteinopathies reputed to be transmissible under field conditions since decades. The transmission of Bovine Spongiform Encephalopathy (BSE) to humans evidenced that an animal PD might be zoonotic under appropriate conditions. Contrarily, in the absence of obvious (epidemiological or experimental) elements supporting a transmission or genetic predispositions, PD, like the other proteinopathies, are reputed to occur spontaneously (atpical animal prion strains, sporadic CJD summing 80% of human prion cases). Non-human primate models provided the first evidences supporting the transmissibiity of human prion strains and the zoonotic potential of BSE. Among them, cynomolgus macaques brought major information for BSE risk assessment for human health (Chen, 2014), according to their phylogenetic proximity to humans and extended lifetime. We used this model to assess the zoonotic potential of other animal PD from bovine, ovine and cervid origins even after very long silent incubation periods. We recently observed the direct transmission of a natural classical scrapie isolate to macaque after a 10-year silent incubation period, with features similar to some reported for human cases of sporadic CJD, albeit requiring fourfold longe incubation than BSE. Scrapie, as recently evoked in humanized mice (Cassard, 2014), is the third potentially zoonotic PD (with BSE and L-type BSE), ***thus questioning the origin of human sporadic cases. We will present an updated panorama of our different transmission studies and discuss the implications of such extended incubation periods on risk assessment of animal PD for human health.   ===============   ***thus questioning the origin of human sporadic cases...TSS   ===============    https://prion2015.files.wordpress.com/2015/05/prion2015abstracts.pdf   Saturday, May 30, 2015   PRION 2015 ORAL AND POSTER CONGRESSIONAL ABSTRACTS    http://transmissiblespongiformencephalopathy.blogspot.com/2015/05/prion-2015-oral-and-poster.html   LATE-BREAKING ABSTRACTS   O18   Zoonotic Potential of CWD Prions   Liuting Qing1, Ignazio Cali1,2, Jue Yuan1, Shenghai Huang3, Diane Kofskey1, Pierluigi Gambetti1, Wenquan Zou1, Qingzhong Kong1 1Case Western Reserve University, Cleveland, Ohio, USA, 2Second University of Naples, Naples, Italy, 3Encore Health Resources, Houston, Texas, USA   Chronic wasting disease (CWD) is a widespread and expanding prion disease in free-ranging and captive cervid species in North America. The zoonotic potential of CWD prions is a serious public health concern. Current literature generated with in vitro methods and in vivo animal models (transgenic mice, macaques and squirrel monkeys) reports conflicting results. The susceptibility of human CNS and peripheral organs to CWD prions remains largely unresolved. In our earlier bioassay experiments using several humanized transgenic mouse lines, we detected protease-resistant PrPSc in the spleen of two out of 140 mice that were intracerebrally inoculated with natural CWD isolates, but PrPSc was not detected in the brain of the same mice. Secondary passages with such PrPSc-positive CWD-inoculated humanized mouse spleen tissues led to efficient prion transmission with clear clinical and pathological signs in both humanized and cervidized transgenic mice. Furthermore, a recent bioassay with natural CWD isolates in a new humanized transgenic mouse line led to clinical prion infection in 2 out of 20 mice. These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection.   ==================   ***These results indicate that the CWD prion has the potential to infect human CNS and peripheral lymphoid tissues and that there might be asymptomatic human carriers of CWD infection.***   ==================    https://prion2015.files.wordpress.com/2015/05/programguide1.pdf   I strenuously once again urge the FDA and its industry constituents, to make it MANDATORY that all ruminant feed be banned to all ruminants, and this should include all cervids as soon as possible for the following reasons...   ======   In the USA, under the Food and Drug Administrations BSE Feed Regulation (21 CFR 589.2000) most material (exceptions include milk, tallow, and gelatin) from deer and elk is prohibited for use in feed for ruminant animals. With regards to feed for non-ruminant animals, under FDA law, CWD positive deer may not be used for any animal feed or feed ingredients. For elk and deer considered at high risk for CWD, the FDA recommends that these animals do not enter the animal feed system.   ***However, this recommendation is guidance and not a requirement by law.   ======    31 Jan 2015 at 20:14 GMT   *** Ruminant feed ban for cervids in the United States? ***   31 Jan 2015 at 20:14 GMT    http://www.plosone.org/annotation/listThread.action?root=85351   Tuesday, June 23, 2015   Report on the monitoring and testing of ruminants for the presence of transmissible spongiform encephalopathies (TSEs) in the EU in 2013 Final version 18 May 2015   http://transmissiblespongiformencephalopathy.blogspot.com/2015/06/report-on-monitoring-and-testing-of.html   Sunday, July 12, 2015   Insights into CWD and BSE species barriers using real-time conversion   http://transmissiblespongiformencephalopathy.blogspot.com/2015/07/insights-into-cwd-and-bse-species.html
_Th3_S0v13t _Fr0stByte_ (1 год назад)
Terry Singeltary Dang... how long did it take you to type all of this? 😕
Louise Eldridge (4 года назад)
It is NOT one in a million, and is not reportable to the CDC.  Many in my small state are victims, and are all ages.  I lost a sister in less than 6 months.  It initially was diagnosed as a sinus infection, which is common.  It's food borne, meat borne, carried by deer and moose.  All victims have food preparation or hunting in common.
lulu mede (13 дней назад)
Where did your sister work?
ron rupska (2 месяца назад)
Louise Eldridge check out Joe Rogan's talk on CJD .....you're right the med community doesn't collect data on this
drwanderlust (2 месяца назад)
exposure to infected or unsterilized tools, as well as brain matter and blood, are equally dangerous. variant cjd is common
vgnorweck (5 месяцев назад)
Louise Eldridge many states dont report and familial is out there too. Some are saying they gave trials now but it should be mandatory to report
Snadyvich Cat (1 год назад)
Cjd Occurs on its own it does not need to be consumed
Kim Lamb (4 года назад)
My cousin just died of this 2 days ago. He walked into a hospital only complaining of dizziness and died 13 days later.
Emma S (1 год назад)
I'm sorry for you
Just Bein' Myself (4 года назад)
A friend's husband died of this a few years ago, He was only about 50 years old.
Hey_Gurl_Hey (5 лет назад)
does'nt seem like one in a millian by what im reading down in the comments..
Charles Benson (5 лет назад)
a buddy of mine died of this
c2a2YT (5 лет назад)
My mother died of it. About 8 weeks from the onset of symptoms to death. It was like living in a nightmare and I'm so sorry for your loss.
_Th3_S0v13t _Fr0stByte_ (1 год назад)
c2a2YT I'm sorry for your loss😢. Don't worry, we will one day find a cure for CJD😐. RIP all killed by CJD, for you will all be in our hearts and memories. 😏💞 #CureCJDForGood
Kelly Shaeffer (5 лет назад)
I have another CJD death to report. My Aunt died July 26, 2013 in St. Louis, MO. She was 65 and also lived in Houston, TX a great deal of her life. It was a quick, unexpected death and apparently very rare here in the US. Since she became ill, I have boycotted anything bovine related and have switched to a plant based diet. I have never felt more healthy in my life.
yolol (1 год назад)
how is that working out for you? sorry about your loss
Greg (5 лет назад)
My father in law has this right now. It is horrible to see someone go through this.
Stephanie (5 лет назад)
I am so sorry for your loss.
Stephanie (5 лет назад)
This is a horrible disease :(
Robert McCeney (5 лет назад)
My dad passed away from CJD in September of 2011. It's a very cruel disease that takes someone away from you while leaving their body to stay alive. I'm not sure why this disease even exists.
djcoolaid1 (6 лет назад)
My father passed of CDJ IN MAY...where can I find the blue wristband that was shown on the video?
Terry Singeltary (6 лет назад)
Monday, July 23, 2012 The National Prion Disease Pathology Surveillance Center July 2012 prionunitusaupdate2008.blogspot.com/2012/07/the-national-prion-disease-pathology.html

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